分野別セミナー

The high lipid concentrations in blood composition can lead to the plaque formation on the
arterial wall known as stenosis. Without treatment, the stenosis can grow in size and cause
severe blockage leading to cardiovascular diseases. Catheterization is one of the treatment
of stenosed artery to widen the narrowed artery. Certain catheterization treatment carries a
drug-eluting stent that causes a chemical reaction between the blood materials and drug
medicine. However, the simultaneous presence of stenosis, catheter and chemical reaction
significantly alters blood flow and solute dispersion dynamics. In this study, we analyse the
effects of catheter radius, stenosis size and chemical reaction rate using the Herschel-
Bulkley model to describe the blood rheology. The governing equations are formulated using
the continuity and momentum equations and solved through the Simpson’s 3/8 rule to obtain
the blood velocity. The solute transport is described by the unsteady convective-diffusion
equation and solved using the Generalized Dispersion Model (GDM) to obtain the dispersion
function, diffusion coefficient and mean solute concentration. This present research provides
insights into the influences of catheterization, stenosis and chemical reaction on blood flow
characteristics and solute dispersion behaviour which can aid in optimizing medical
treatments and drug delivery strategies.