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Colloquiums (FM & IMI)

Sensitivity of chemical reaction networks: a structural approach

Hold Date
2015-05-20 16:45~2015-05-20 17:45
Place
Lecture Room L-1 (3F, IMI, Kyushu University)
Object person
 
Speaker
Atsushi MOCHIZUKI (Theoretical Biology Laboratory, RIKEN / CREST, Japan Science and Technology Agency)

The IMI Colloquium in May
 
Date:Wednesday, 20 May 2015
          16:45-17:45 lecture
Place:Lecture Room L-1 (3F, IMI, Kyushu University)
Speaker:Atsushi MOCHIZUKI
              (Theoretical Biology Laboratory, RIKEN / CREST, Japan Science and Technology Agency)
 
Title:Sensitivity of chemical reaction networks: a structural approach
 
Abstract:
In biological cells, chemical reaction pathways lead to complex network systems like metabolic networks. One experimental approach to the dynamics of such systems examines their "sensitivity": each enzyme mediating a reaction in the system is increased/decreased or knocked out separately, and the responses in the concentrations of chemicals or their fluxes are observed. In this study, we present a mathematical method, named "structural sensitivity analysis", to determine the sensitivity of reaction systems from information on the network alone. We investigate how the sensitivity responses of chemicals in a reaction network depend on the structure of the network, and on the position of the perturbed reaction in the network. We establish and prove some general rules which relate the sensitivity response to the structure of the underlying network. We describe a hierarchical pattern in the flux response which is governed by branchings in the network. We apply our method to several hypothetical and real life chemical reaction networks, including the metabolic network of the E. coli TCA cycle. This study is a collaboration work with Prof. Bernold Fiedler (Free Univ. Berlin, Germany).
  Mochizuki A. & Fiedler B. J. Theor. Biol. (2015) 367, 189-202.
  Fiedler & Mochizuki Math. Meth. Appl. Sci. (In Press)
 


IMI Colloquium Report